Rectal Suppositories 500mg

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The product is developed based on the research conducted by a group of eminent scientists Mahmoud A. ElSohlya,  Waseem Gula,  Larry A. Walkera, via article ( Tolerability of Δ9-THC-Hemisuccinate in a Suppository Formulation as an Alternative to Capsules )  .Study finds out oral absorption is slow and erratic, and the “first-pass” metabolic effect is high, so that when administered orally, there is a variable peak in Δ9 -THC in plasma ranging from 45 min to a few hours, and an overall systemic bioavailability of about 10% . In addition to these pharmacokinetic considerations, the use of capsules in many of these indications can be limited by nausea, vomiting, or difficulty in swallowing. Alternatives for systemic delivery of CBD + THC based formulations via suppository administration is one of the methodologies .

Cannabis suppositories are a lesser-known but potentially effective method for pain management. Here's an overview of their role:

1. **Direct Delivery**: Suppositories offer a unique route of administration that allows for the direct delivery of cannabinoids to the bloodstream without the need for digestion. This can result in faster onset of action and higher bioavailability compared to oral ingestion.

2. **Avoidance of GI Tract**: For individuals who may have gastrointestinal issues or difficulty swallowing, suppositories provide an alternative method of administration that bypasses the digestive system, reducing the likelihood of gastrointestinal side effects.

3. **Localized Effect**: Depending on the formulation, cannabis suppositories can be designed to target specific areas of pain or inflammation, providing localized relief. This is particularly beneficial for conditions such as pelvic pain, menstrual cramps, and rectal discomfort.

4. **Longer Duration of Action**: Suppositories tend to have a longer duration of action compared to other routes of administration, as they are slowly absorbed over time. This can result in sustained pain relief without the need for frequent dosing.

5. **Reduced Psychoactive Effects**: When cannabis suppositories are formulated with higher ratios of CBD to THC, they may provide therapeutic benefits with minimal psychoactive effects. This makes them suitable for individuals who want to avoid or minimize the "high" associated with THC.

6. **Potential for Synergistic Effects**: Cannabis suppositories can be formulated with different cannabinoid ratios and terpenes to harness the entourage effect, where the combined action of multiple cannabis compounds may produce enhanced therapeutic effects.

7. **Alternative for Patients Unable to Use Other Routes**: In some cases, patients may be unable to use oral or inhalation methods of cannabis administration due to medical conditions or personal preferences. Suppositories offer a viable alternative for such individuals.

It's important to note that while cannabis suppositories show promise in pain management, more research is needed to fully understand their efficacy, optimal dosing, and safety profile. Additionally, individual responses to suppositories may vary, and healthcare providers should carefully assess patients and monitor their response to treatment. As with any form of medical cannabis, it's essential to consult with a qualified healthcare provider for personalized guidance and recommendations.

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